4-dedimethylamino tetracycline compounds

A tetracycline compound of formula IV:

• wherein:
• X is CHC(R13Y′Y), or CR6′R6;
• R2 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, aryl, heterocyclic or heteroaromatic;
• R7′ and R7″ are each alkyl;
• R4 and R4′ are each independently alkyl, alkenyl, alkynyl, aryl, hydroxyl, alkoxy, halogen, hydrogen, or taken together to form the oxygen of a carbonyl;
• R2′, R3, R10, R11 and R12 are each hydrogen;
• R5 is hydroxyl hydrogen, thiol, alkanoyl, aroyl, alkaroyl, aryl, heteroaromatic, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, alkyl carbonyloxy, or aryl carbonyloxy;
• R6 and R6′ are independently hydrogen, methylene, hydroxyl, halogen, thiol, alkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, or an arylalkyl;
• R7 is NR7′R7″;
• R9 is alkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, arylalkyl, amido, acyl, arylalkenyl, arylalkynyl, thionitroso, or —(CH2)0-3NR9cC(=Z′)ZR9a;
• Z is CR9dR9e, S, NR9b or O;
• Z′ is NR9f, O or S;
• R9a, R9b, R9c, R9d, R9e and R9f are each independently hydrogen, acyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, aryl, heterocyclic or heteroaromatic;
• R8 is hydrogen, hydroxyl, thiol, alkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, or an arylalkyl;
• R13 is hydrogen, hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, or an arylalkyl;
• Y′ and Y are each independently hydrogen, halogen, hydroxyl, cyano, sulfhydryl, amino, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, or an arylalkyl, and pharmaceutically acceptable salts, esters and amides thereof.