Sulfur analogues of 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) for treating excess of glucocorticoids
AssigneeApplied Research Systems ARS Holding N.V.
InventorsGerardo Burton, Carlos P. Lantos, Adriana Silvia Veleiro
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Abstract
The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of disease associated to an excess of glucocorticoids. In particular, the invention relates to the use of novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues for treating Cushing's syndrome, iatrogenic hypercortisolism or depression. Also the present invention is related to methods of preparing the novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues.
Claims21
A compound of formula (II)
- wherein X is S, SO or SO2, and R is either H or OH.
A compound of formula (IIa)
- wherein X is SO or SO2.
A pharmaceutical composition comprising at least one 21-hydroxy-6, 19-oxido-progesterone analog of formula II:
- wherein X is S, SO or SO2, and R is either H or OH
- and one or more suitable carriers thereof.
Dependencies are inferred from the claim text.