Nucleoside analogs and oligonucleotide derivatives containing these analogs
AssigneeTakeshi Imanishi
InventorsTakeshi Imanishi, Satoshi Obika
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Abstract
Nucleoside analogues expressed by the following general formula where B represents an aromatic base having carbonyl oxygen at the 2-position, or a 2-hydroxyphenyl group, or oligonucleotide derivatives containing one or more of the nucleoside analogues are provided. The oligonucleotide derivatives are triplex-forming oligonucleotide derivatives which bind specifically to target double-stranded DNA with high affinity in the antigene method to form triplexes, and can thereby control and inhibit the expression of relevant genes efficiently, and which show high resistance to nucleases.
Claims10
Nucleoside analogues expressed by the following general formula (I)
- where B represents a substituent selected from substituents expressed by the following general formulas
- where J, K, L and Q are identical or different, and each denote —H, a lower alkyl, —OH, or —NH2, 1, m and p independently denote an integer of 1 to 4, and n denotes an integer of 1 or 2,
- X and Y are identical or different, and each represent hydrogen, an alkyl group, an alkenyl group, an alkinyl group, a cycloalkyl group, an aralkyl group, an aryl group, an acyl group, or a silyl group,
- or amidite derivatives thereof.
Dependencies are inferred from the claim text.