Dendritic cell potentiation
AssigneeMayo Foundation for Medical Education and Research
InventorsLarry R. Pease, Moses Rodriguez, Daren Ure, Loc T. Nguyen, Suresh Radhakrishnan
Life of this patent
Estimating the term…
Abstract
A molecule capable of potentiating immune responses is described, as well as methods for using the molecule to enhance immune responses and enhance dendritic cell function. Also described are compositions containing the molecule and methods for using the compositions to treat or immunize individuals.
Claims21
A purified IgM antibody that binds to B7-DC polypeptides on a cell, wherein said binding results in cross-linking of a plurality of said B7-DC polypeptides, and wherein said IgM. antibody can potentiate an immune response upon administration to a mammal.
A purified IgM antibody that binds to B7-DC polypeptides on a cell, wherein said binding results in cross-linking of a plurality of said B7-DC polypeptides, and wherein dendritic cells contacted with said molecule exhibit at least one characteristic selected from the group consisting of prolonged longevity, increased NF-κB expression, increased NF-κB translocation to the nucleus, increased ability to activate naive T cells, increased phosphorylation of Akt, increased localization to lymph nodes upon administration to a mammal, maintenance of metabolic rate in culture after cytokine withdrawal, and increased IL-12 secretion.
Dependencies are inferred from the claim text.