Method for producing therapeutically suitable glutaminase
AssigneesME Medical Enzymes AG, Joseph Roberts
InventorsJoseph Roberts, Thomas W MacAllister, Natarajan Sethuraman, Abbie G. Freeman
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Abstract
DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent anti-viral agent and when coupled to an anti-tumor monoclonal antibody is a potent anticancer agent. The glutaminase of the present invention is particularly useful for treating lung, breast and colon cancer cells and in the treatment of HIV-infected cells.
Claims6
A method of producing a therapeutically suitable glutaminase comprising:
- culturing a recombinant microorganism which comprises a heterologous nucleotide sequence that codes for a therapeutically suitable glutaminase;
- and
- collecting said therapeutically suitable glutaminase produced by said microorganism, wherein said nucleotide sequence encodes the protein of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.