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AssigneeTakeda Pharmaceutical Company Limited
InventorsYasuaki Itoh, Nobuhiro Suzuki, Kazunori Nishi, Hideki Kizawa, Masataka Harada, Kazuhiro Ogi
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The present invention relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:8 (B chain), (3) a polypeptide wherein the A and B chains are bonded to each other via disulfide bonds (2 chains) or its salt, (4) DNAs encoding the same, etc. These polypeptides and DNAs encoding the same can be used for the diagnosis, treatment, prevention, etc. for diseases, including abnormalities (e.g., diabetes mellitus, etc.) in metabolic regulation (sugar metabolism, lipid metabolism, etc.) of energy sources such as carbohydrates.
An isolated polypeptide having the amino acid sequence represented by SEQ ID NO:7, its amide or ester, or a salt thereof or the amino acid sequence represented by SEQ ID NO:8, its amide or ester, or a salt thereof.
A method for making a pharmaceutical for preventing or treating abnormality of metabolic regulation inhibition of growth/proliferation/differentiation of tissue, hypogonadism, dysplasia of connective tissue, fibrillation of tissue, circulatory disorders, endocrine disruption, abnormality of body fluid balance, central disease, immune system disease or angiogenic disorder, comprising combining an effective amount of a polypeptide comprising the amino acid sequence represented by SEQ ID NO:7, or the amino acid sequence represented by SEQ ID NO:8, its amide or ester, or a salt thereof, with a pharmaceutically acceptable carrier, diluent or excipient.
Dependencies are inferred from the claim text.