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US 7,049,136 B2Granted
Redirection of cellular immunity by receptor chimeras
AssigneeThe General Hospital Corporation
InventorsBrian Seed, Charles Romeo, Waldemar Kolanus
Life of this patent
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Abstract
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.
Claims13
A cell expressing a proteinaceous membrane-bound chimeric receptor,
- the first of said receptor comprising (a) an extracellular portion which is capable of specifically recognizing and binding a target cell or a target infective agent, (b) a transmembrane portion derived from a T cell receptor, a B cell receptor, or an Fc receptor protein which, in the absence of an intracellular signalling domain, is capable of signalling said cell to destroy a receptor-bound target cell or a receptor-bound target infective agent, and (c) an intracellular domain that does not signal said cell to destroy a receptor-bound target cell or receptor-bound target infective agent;
- and
- the second of said receptors comprising (a) an extracellular portion which is capable of specifically recoginizing and binding said target cell or said target infective agent, and (b) an intracellular portion which is derived for CD28.
A cell which expresses at least two proteinaceous membrane-bound chimeric receptors,
- the first of said receptors comprising (a) an extracellular portion which is capable of specifically recognizing and binding a target cell or a target infective agent, and (b) a transmembrane portion derived from a T cell receptor CD3, zeta, or eta polypeptide, a B cell receptor, or an Fc receptor, and (c) an intracellular domain that does not signal target cell or target infective agent destruction;
- and
- the second of said receptors comprising (a) an extracellular portion which is capable of specifically recognizing and binding said target cell or said target infective agent, and (b) an intracellular portion which is derived from CD28.
Dependencies are inferred from the claim text.