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US 7,049,121 B2Granted
Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
AssigneeApplied Molecular Evolution, Inc.
InventorsJeffry D Watkins, James D Pancook
Life of this patent
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Abstract
The invention provides twenty-one butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
Claims10
A butyrylcholinesterase variant polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 2, 4, 6, 8, 10, 12, 14, 16, and 18.
Dependencies are inferred from the claim text.