Tissue engineered uterus
AssigneeChildren's Medical Center Corporation
InventorsAnthony Atala, James J. Yoo
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Abstract
The invention is directed to compositions and methods for reconstructing artificial female reproductive organs. The constructs and methods of the invention can be used for ameliorating congenital malformations and disorders of female reproductive tract using tissue engineered female reproductive organs, such as the uterus, vagina, cervix, and fallopian tubes. These tissue engineered female reproductive organs can be generated by perfusing cultured cell populations derived from cells of the female reproductive tissues, such as uterine, vaginal, cervical, fallopian tube epithelial cells as well as smooth muscle cells.
Claims6
An artificial uterus tissue construct for repair or reconstruction of the uterus comprising:
- an implantable, biocompatible matrix with a multilayered structure of uterine epithelial and smooth muscle cells, the construct being formed by perfusion of one side of the matrix with a uterine epithelial cell population and with a smooth muscle cell population, such that the uterine epithelial cell population attaches to the smooth muscle cell population to form a tissue structure that is a functional equivalent of normal uterus tissue.
Dependencies are inferred from the claim text.