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US 7,041,870 B2Granted
Transgenic transchromosomal rodents for making human antibodies
AssigneesMedarex, Inc., Kirin Brewery Co., Ltd.
InventorsKazuma Tomizuka, Isao Ishida, Nils Lonberg, Edward L. Halk
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Abstract
The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
Claims4
A transgenic mouse comprising two human immunoglobulin loci, wherein one of said human immunoglobulin loci is a human heavy chain locus and the other locus is a human light chain locus;
- wherein the human heavy chain locus is carried by transchromosome SC20 and the human light chain locus is carried by a transgene integrated into the genome of said mouse;
- and wherein an endogenous mouse heavy chain locus and at least one endogenous mouse light chain locus are inactivated.
Dependencies are inferred from the claim text.