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US 7,041,844 B2Granted
Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
AssigneeThe University of Tennessee Research Corporation
InventorsDuane D. Miller, Leonid I. Kirkovsky, James T. Dalton, Arnab Mukherjee
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Abstract
The present invention relates to an antiandrogen compound and a method of treating prostate cancer in a patient utilizing the compound. The present invention also relates to a pharmaceutical composition which includes the compound.
Claims4
A compound having the formula
- where
- R is F, NH2, NCS, N3, or NHCOCH2Y;
- Y is a halogen
- wherein if R is NHCOCH2Y or NCS then
- Z is CN;
- if R is F, NH2 or N3, then Z is NCS;
- and
- wherein the compound binds irreversibly to an androgen receptor of a mammal.
5 more elements
A pharmaceutical composition comprising a compound, wherein the compound has the formula:
- where
- R is F, NH2, NCS, N3, or NHCOCH2Y;
- Y is a halogen
- wherein if R is NHCOCH2Y or NCS then
- Z is CN;
- if R is F, NH2 or N3, then Z is NCS;
- and
- wherein the compound binds irreversibly to an androgen receptor of a mammal.
5 more elements
Dependencies are inferred from the claim text.