Stent for controlled release of drug
AssigneeBoston Scientific Scimed, Inc.
InventorsJohn T. Santini, Jr., Charles E. Hutchinson
Life of this patent
Estimating the term…
Abstract
Devices for the controlled release of one or more drugs into a patient are provided. The devices include an implantable stent, at least two reservoirs in the stent, and a release system contained in each of the at least two reservoirs, wherein the release system may have one or more drugs for release at a controlled rate. Reservoir caps optionally are provided to control the time at which release of the one or more drugs is initiated.
Claims72
A device for the controlled release of one or more drugs, comprising:
- an implantable stent having at least two reservoirs therein, wherein each reservoir defines an opening in the implantable stent;
- at least two discrete reservoir caps, wherein each discrete reservoir cap covers substantially the entire opening defined by a respective reservoir;
- and
- a release system contained in each of the at least two reservoirs, wherein the release system comprises one or more drugs for release at a controlled rate.
A device for the controlled release of one or more drugs, comprising:
- an implantable non-degradable stent;
- at least two reservoirs in the stent, wherein each of the at least two reservoirs are covered by a discrete reservoir cap;
- and a release system contained in each of the at least two reservoirs, wherein the release system comprises one or more drugs for release at a controlled rate,
- wherein each discrete reservoir cap are disintegrable in vivo to control the time of release of the one or more drugs.
A device for the controlled release of one or more drugs, comprising:
- an implantable metallic stent;
- at least two reservoirs in the stent;
- and a release system, contained in each of the at least two reservoirs, the release system comprising two or more layers of a biodegradable or water-soluble matrix material and a therapeutic agent distributed therein;
- wherein the matrix material degrades or dissolves in vivo to controllably release the therapeutic agent.
A method for delivering a therapeutic agent into a patient comprising:
- implanting a metallic stent at a site in a patient, the stent comprising a plurality of reservoirs containing a release system, wherein the release system comprising two or more layers of a biodegradable or water-soluble matrix material and a therapeutic agent distributed therein;
- and
- contacting the matrix with one or more biological tissues or fluids in vivo to cause the matrix to degrade or dissolve, thereby releasing the therapeutic agent into the patient at a controlled rate.
A method for delivering a therapeutic agent into a patient comprising:
- implanting a metallic stent at a site in a patient, the stent comprising at least two reservoirs in the stent wherein each of the at least two reservoirs are covered by a discrete reservoir cap, a release system contained in each of the at least two reservoirs, the release system comprising a therapeutic agent, wherein each discrete reservoir cap is disintegrable in vivo to control the time of release of the therapeutic agent;
- contacting the reservoir caps with one or more biological tissues or fluids in vivo to cause the reservoir cap to degrade or dissolve;
- and then
- contacting the release system with the one or more biological tissues or fluids in vivo to cause the therapeutic agent to be released at a controlled rate into the patient.
Dependencies are inferred from the claim text.