Indirect measurement of tissue analytes through tissue properties

A method for noninvasive measurement of a target analyte in a tissue, comprising the steps of:

• collecting an analytical signal from the tissue, said collected signal comprising tissue measurement;
• extracting at least one feature from the analytical signal indicative of the effect of the target analyte on the probed tissue, wherein said effect comprises alteration of water distribution among body compartments;
• and
• either correcting a direct analyte measurement based on said at least one feature;
• or
• calculating concentration of said analyte indirectly by application of a calibration model to said at least one feature.

A method for noninvasive measurement of a target analyte in a tissue, comprising the steps of:

• collecting an analytical signal from the tissue, said collected signal comprising a tissue measurement;
• extracting at least one feature from the analytical signal indicative of the effect of the target analyte on the probed tissue wherein said at least one feature comprises at least a portion of a water band, a portion of a fat band, and a portion of a protein band;
• either correcting a direct analyte measurement based on said at least one feature;
• or
• calculating concentration of said analyte indirectly by application of a calibration model to said at least one feature.

A method for noninvasive measurement of a target analyte in a tissue, comprising the steps of:

• collecting an analytical signal from the tissue, said collected signal comprising a tissue measurement;
• preprocessing said tissue measurement;
• extracting at least one feature from the analytical signal indicative of the effect of the target analyte on the probed tissue;
• and
• either correcting a direct analyte measurement based on said at least one feature;
• or
• calculating concentration of said analyte indirectly by application of a calibration model to said at least one feature.