Removing compounds from blood products with porous particles immobilized in a matrix
AssigneeCerus Corporation
InventorDerek J. Hei
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Abstract
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix.
Claims46
A method of reducing the concentration of a low molecular weight compound in an aqueous cell-containing blood product, wherein the method comprises contacting the cell-containing blood product batch-wise with an adsorption medium comprising porous adsorbent particles immobilized within a sintered matrix formed from polymeric particulate material and adsorbing said low molecular weight compound, wherein the diameter of the adsorbent particles ranges from about 100 μm to about 1500 μm, wherein the adsorbent particles have an affinity for said low molecular weight compound, and wherein the cell-containing blood product-maintains sufficient biological activity so that said cell-containing blood product is suitable for infusion within a human.
Dependencies are inferred from the claim text.