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US 7,037,508 B2Granted
Pestivirus mutants and vaccines containing the same
AssigneeAkzo Nobel N.V.
InventorsHeinz-Jürgen Thiel, Paul P. Becher, Michaela M. Orlich
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Abstract
The present invention is directed to attenuated pestivirus mutants, which have a reduced ability to replicate as exhibited by a small plaque size. The mutations are in the 5′ nontranslated region of the viral genome. These mutant viruses are useful as live vaccines in the control of bovine viral diarrhea, border disease and classical swine fever.
Claims23
An attenuated isolated pestivirus mutant having a growth-restricted phenotype relative to a wild-type pestivirus, said mutant comprising:
- one or more mutations of stem loops 1a and/or 1b of the 5′ nontranslated region (NTR) of the pestivirus genome, and wherein the mutated 5′ end of the genome conserves the nucleotide sequence 5′ -GUAU and expression of a viral poly protein from said genome is under the control of a homologous internal ribosome entry site (IRES).
Dependencies are inferred from the claim text.