Phosphonate compounds
AssigneeThe Regents of the University of California
InventorsKarl Y. Hostetler, James R. Beadle, Ganesh D. Kini
Life of this patent
Estimating the term…
Abstract
The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
Claims75
A compound, having a phosphonate ester formed by a covalent linking of an antiviral compound selected from the group consisting of cidofovir, adefovir, cyclic cidofovir and tenofovir, to an alcohol selected from the group consisting of an alkylglycerol, alkylpropanediol, 1-S-alkylthioglycerol, alkoxyalkanol or alkylethanediol, or a pharmaceutically acceptable salt thereof.
1-O-octadecylpropanediol-3-cidofovir.
1-O-octadecylethanediol-2-cidofovir.
1-O-hexadecylpropanediol-3-cidofovir.
1-O-hexadecylpropanediol-3-cyclic cidofovir.
1-O-octadecylpropanediol-3-cyclic cidofovir.
1-O-octadecylethanediol-2-cyclic cidofovir.
1-O-hexadecylpropanediol-3-adefovir.
1-O-octadecyl-sn-glycero-3-adefovir.
Dependencies are inferred from the claim text.