Methods and means for targeted gene delivery

A kit of parts for delivering genetic material to a target cell, comprising:

• a gene delivery vehicle comprising an expressible nucleic acid molecule encoding a gene of interest, a virus including a capsid or envelope surrounding said expressible nucleic acid molecule, and a first member of a specific binding pair;
• said first member of the specific binding pair expressed by recombinant expression on an exterior of said capsid or envelope;
• and
• a bispecific conjugate for coupling to said first member of the specific binding pair, said bispecific conjugate comprising a second member of the specific binding pair covalently coupled to a targeting moiety, said targeting moiety capable of binding to a target molecule associated with a surface of the target cell, wherein said first member of the specific binding pair comprises an immunoglobulin binding moiety that is capable of binding to a constant region of an immunoglobulin.

A targeted gene delivery vehicle complex, said targeting gene delivery vehicle complex comprising:

• a gene delivery vehicle coupled with a bispecific conjugate, said gene delivery vehicle comprising:
• an expressible nucleic acid molecule encoding a gene of interest, a virus including a capsid or envelope surrounding said expressible nucleic acid molecule, and a first member of a specific binding pair,
• said first member of the specific binding pair being recombinantly expressed on an exterior of said capsid or envelope;
• and wherein said first member of the specific binding pair comprises an immunoglobulin binding moiety that is capable of binding to a constant region of an immunoglobulin;
• wherein said bispecific conjugate comprises a second member of said specific binding pair covalently coupled to a targeting moiety capable of binding to a target molecule associated with the surface of said target cell.

A gene delivery vehicle comprising:

• an expressible nucleic acid molecule encoding a gene of interest,
• a virus including a capsid or envelope surrounding said expressible nucleic acid molecule, and
• a first member of a specific binding pair,
• said first member of the specific binding pair being recombinantly expressed on an exterior of said capsid or envelope, and said first member of the specific binding pair comprising an immunoglobulin binding moiety that is capable of binding to a constant region of an immunoglobulin.