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US 7,030,374 B2Granted
Ion fragmentation in RF ion traps by electron capture with magnetic field
AssigneeBruker Daltonik GmbH
InventorJochen Franzen
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Abstract
The invention relates to a method and device for the fragmentation of macromolecules, preferably biomolecules, by electron capture in RF quadrupole ion trap mass spectrometers according to Wolfgang Paul. The invention comprises steering a beam of low energy electrons through a magnetic guide field exactly into an ion cloud in the center of the ion trap.
Claims11
Method for the fragmentation of ions in an RF ion trap mass spectrometer by the capture of low energy electrons (ECD), comprising the following steps:
- (a) providing an RF ion trap with a ring electrode and two end cap electrodes, operated by an RF voltage,
- (b) providing an electron emitter outside the ion trap,
- (c) providing a pressure of damping gas inside the ion trap,
- (c) providing a cloud of selected parent ions inside the ion trap collecting in the center of the trap,
- (d) providing a magnetic field with field lines reaching from the electron emitter to the ion cloud, and
- (e) injecting electrons into the trap, whereby the electrons follow the magnetic field lines to the ion cloud.
3 more elements
Ion trap mass spectrometer apparatus, comprising
- (a) an RF ion trap mass spectrometer,
- (b) an electron emitter for the generation of an electron beam outside the ion trap, and
- (c) a magnetic field generator for the generation of a magnetic field the field lines of which reach from the electron emitter to the center of the ion trap.
Dependencies are inferred from the claim text.