CYT28 serpentine receptor disruptions, compositions and methods relating thereto
AssigneeDeltagen, Inc.
InventorKeith D. Allen
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Abstract
The present invention relates to compositions and methods relating to the characterization and function of CYT28. Specifically, the present invention provides transgenic animals comprising disruptions in a CYT28 gene and methods of treating diseases conditions, such as pain. The present invention further relates to agents that modulate CYT28 and methods of screening for agents that modulate CYT28 for the treatment of diseases and conditions such as pain.
Claims7
A transgenic mouse whose genome is homozygous for a null allele of the endogenous CYT28 gene, said null allele comprising exogenous DNA comprising a positive selection marker, said mouse exhibiting dysplasia of the layers of the cerebellar cortex.
Dependencies are inferred from the claim text.