Caenorhabditis elegans strain HD8: a mutant exhibiting constitutive pharyngeal pumping
AssigneeDevgen NV
InventorsPhilippe Verwaerde, Richard Feichtinger, Myriam Behgyn, Thierry Bogaert
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Abstract
The invention provides methods of screening compounds for potential pharmacological activity using nematode worms, principally but not exclusively the nematode C. elegans. Specifically, the invention relates to the use of nematodes modified to have certain characteristics which provide advantages for compound screening, such as constitutive pharyngeal pumping, increased gut permeability or altered gut molecular transport. Methods for selecting suitably modified nematodes from a population of nematodes are also provided.
Claims2
A C. elegans mutant HD8 (LMBP 5447CB) nematode.
A composition comprising C. elegans mutant HD8 (LMBP 5447CB) nematodes.
Dependencies are inferred from the claim text.