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US 7,030,280 B2Granted
Process for producing optically active β-trifluoromethyl-β-hydroxycarbonyl compound
AssigneeCentral Glass Company, Limited
InventorsKazumasa Funabiki, Hitoshi Yamamoto, Masashi Nagamori, Masaki Matsui
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Abstract
The present invention provides a process for producing an optically active β-trifluoromethyl-β-hydroxycarbonyl compound represented by formula (3): comprising a step of reacting a fluoral equivalent represented by formula (1): with a carbonyl compound represented by formula (2): in the presence of an optically active amino acid or a derivative thereof.
Claims20
A process for producing an optically active β-trifluoromethyl-β-hydroxycarbonyl compound represented by formula (3):
- wherein R1 represents a hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms or a hydroxyl group, R2 represents a hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms or an aryl group, or R1 and R2 may be covalently bonded to form a cyclic ketone, and the symbol * represents an asymmetric carbon,
- the process comprising a step of reacting a fluoral equivalent represented by formula (1):
- wherein R represents a hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms or a lower haloalkyl group having 1 to 4 carbon atoms,
- with a carbonyl compound represented by formula (2):
- wherein R1 and R2 each have the same meaning as those defined in formula (3),
- in the presence of an optically active amino acid or a derivative thereof.
3 more elements
Dependencies are inferred from the claim text.