Process for preparing 2-[(dimethylamino)-methyl]-1-(3-methoxyphenyl)cyclohexanol
AssigneeGruenenthal GmbH
InventorsMichael Finkam, Bernhard Akteries
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Abstract
A process for preparing 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol with high stereoselectivity and high yield by reacting 2-[(dimethylamino)methyl]-cyclohexanone in a Grignard reaction with a Grignard compound of 3-bromoanisole in a suitable solvent and in the presence of an inorganic lithium salt and an α,ω-dialkoxyalkane.
Claims14
A process for preparing 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol, said process comprising reacting 2-[(dimethylamino)methyl]cyclohexanone in a Grignard reaction with a Grignard compound of 3-bromoanisole in a suitable solvent and in the presence of an inorganic lithium salt and an α,ω-di-(C1-3)-alkoxy-(C1–C3)-alkane.
Dependencies are inferred from the claim text.