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US 7,030,252 B2Granted
Method for the preparation of citalopram
AssigneeH. Lundbeck A/S
InventorHans Petersen
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Abstract
A method for the preparation of citalopram comprising reductive hydrolysis of a compound of Formula (IV) wherein R is a N,N-disubstituted amid group or an optionally substituted 4,5-dihydro-1,3-oxazol-2-yl group, and conversion of the resulting 5-formyl compound to citalopram.
Claims20
A method for the preparation of citalopram comprising the step of converting the 5-formyl compound of Formula V:
- to the corresponding 5-cyano compound, citalopram
A method for the preparation of the S-enantiomer of citalopram comprising the step of converting the S-enantiomer of the 5-formyl compound of Formula V:
- to the corresponding 5-cyano compound, S-citalopram.
Dependencies are inferred from the claim text.