Tetrahydroquinoline derivatives as stat6-modulators, preparation and use thereof

compound of formula (I):

• wherein:
• L is CH2, O or S;
• n is 0 or 1;
• W, Y and Z are, independently hydrogen, cyano, nitro, halogen, N3, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkylthio, C3-6 cycloalkyl, CO2H, CO2(C1-6 alkyl), CONR5R6, COR10 SO2R12, methylenedioxy, NHCOR11 or heterocyclyl;
• R2 is aryl or heteroaryl optionally substituted by cyano, nitro, halogen, N3, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkylthio, C3-6 cycloalkyl, CO2H, CO2(C1-6 alkyl), CONR13 R14, COR15, SO2R16, methylenedioxy, NHCOR17 or heterocyclyl;
• R3 is C1-4 alkyl or C1-4 haloalkyl;
• R4 is CO(C1-4 alkyl) or CO(C1-4 haloalkyl);
• X is O, S, SO, SO2, CR7R8or NR9;
• R5, R6, R7, R8, R13 and R14 are, independently, hydrogen or C1-6 alkyl;
• R9 is hydrogen, C1-6 alkyl or CO(C1-4 alkyl);
• R10, R11, R12, R15, R16 and R17 are, independently, C1-6 alkyl or phenyl;
• or a pharmaceutically acceptable salt thereof;
• or a solvate thereof;
• provided that the compound of formula (I) is not a compound of formula (Iz):
• (Iz)
• wherein
• R1b
• R1d
• R1c
• R4′
• R2
• R9
• H
• H
• H
• n-butyl
• C6H5
• H
• H
• H
• H
• n-propyl
• C6H5
• COCH3
• H
• H
• H
• n-propyl
• C6H5
• H
• H
• H
• H
• Ethyl
• C6H5
• H
• Br
• H
• H
• Methyl
• C6H5
• COCH3
• Methyl
• H
• H
• Methyl
• 4-CH3—C6H4
• H
• Methyl
• Methyl
• H
• Methyl
• 2,4-(CH3)2—C6H3
• H
• H
• H
• H
• Methyl
• C6H5
• H
• NO2
• H
• H
• Methyl
• 4-NO2—C6H4
• COCH3
• NO2
• H
• H
• Methyl
• C6H5
• COCH3
• Cl
• H
• H
• Methyl
• C6H5
• COCH3
• H
• H
• H
• Methyl
• C6H5
• COCH3
• H
• H
• H
• Methyl
• 2,4-Br2—C6H3
• COCH3
• in free base or unsolvated form.