Antisense oligonucleotides tarageting folate receptor alpha, and the use thereof
OwnerMona Savitri Jhaveri, Patrick Clay Elwood +1inventors
InventorsMona Savitri Jhaveri, Patrick Clay Elwood, Koong-Nah Chung
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Abstract
The invention relates to treatment of cancers and cancerous cells which over-express α folate receptor (FRα) compared to the normal cells of the same tissue. The invention is directed to antisense oligonucleotides which are complimentary to the coding region of FRα, as well as the pharmaceutical compositions made thereof, and the methods of using the same for treatment of cancers, e.g. cancers of ovary, cervix, uterus, and brain.
Claims11
An antisense oligonucleotide complementary to a region of the open reading frame of ∀αhFR (SEQ ID NO:1) as shown in FIG. 9, wherein said antisense oligonucleotide is AS6 (SEQ ID NO:4).
Dependencies are inferred from the claim text.