E25A protein, methods for producing and use thereof
AssigneeThe Regents of the University of California
InventorsRobert E. Reiter, Owen N. Witte, Charles L. Sawyers
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Abstract
The invention provides a human E25a protein which is upregulated in cancerous cells, including those of hormone refractory prostate cancer, colon cancer, breast cancer or other cancers of epithelial origin. The invention also provides nucleic acid molecules encoding E25a protein, nucleic acid probes which hybridize with nucleic acid molecules encoding E25a protein, and antibodies which bind E25a protein. E25a protein and its related molecules can be useful as diagnostic markers of cancer, including hormone refractory prostate cancer, and as specific therapeutic targets in this disease. The invention also provides methods for diagnosing cancer, including hormone refractory prostate cancer.
Claims15
An isolated nucleic acid molecule comprising the nucleotide sequence as shown in FIG. 1 (SEQ ID NO. 1) or comprising the nucleic acid molecule inserted in a vector deposited as ATCC Accession No. 209233.
An isolated nucleic acid molecule comprising the nucleotide sequence as shown in FIG. 1 (SEQ ID NO. 1).
An isolated nucleic acid molecule comprising the nucleic acid molecule inserted in a vector deposited as ATCC Accession No. 209233.
An isolated nucleic acid consisting of the nucleotide sequence as shown in FIG. 1 (SEQ ID NO:
- 1).
An isolated nucleic acid consisting of the molecule inserted in a vector deposited a ATCC Accession No. 209233.
Dependencies are inferred from the claim text.