Antibodies to JTT-1 protein, cells secreting such antibodies, and methods of making such antibodies

A process for producing a cell which secretes an antibody that binds to a polypeptide consisting of SEQ ID NO:2, comprising:

• i) immunizing a mammal with an immunogen selected from the group consisting of:
• a) an isolated polypeptide consisting of SEQ ID NO:
• 2;
• b) an isolated polypeptide comprising the extracellular region of SEQ ID NO:2;
• c) an isolated homodimer molecule consisting of two polypeptide defined in a) or two polypeptides defined in b);
• and
• d) a recombinant cell transfected with a DNA encoding a polypeptide consisting of SEQ ID NO:2, wherein the cell expresses the polypeptide;
• ii) obtaining from the mammal cells that secrete antibodies, or generating from cells of the mammal cell lines that secrete antibodies;
• and
• iii) identifying from the cells obtained in ii) or from the cell lines generated in ii) a cell that secretes an antibody that binds to a polypeptide consisting of SEQ ID NO:2.

A process for producing a cell which secretes an antibody that binds to a polypeptide consisting of SEQ ID NO:14, comprising:

• i) immunizing a mammal with an immunogen selected from the group consisting of:
• a) an isolated polypeptide consisting of SEQ ID NO:14;
• b) an isolated polypeptide comprising the extracellular region of SEQ ID NO:14;
• c) an isolated homodimer molecule consisting of two polypeptide defined in a) or two polypeptides defined in b);
• and
• d) a recombinant cell transfected with a DNA encoding a polypeptide consisting of SEQ ID NO:
• 14, wherein the cell expresses the polypeptide;
• ii) obtaining from the mammal cells that secrete antibodies, or generating from cells of the mammal cell lines that secrete antibodies;
• and
• ii) identifying from the cells obtained in ii) or from the cell lines generated in ii) a cell that secretes an antibody that binds to a polypeptide consisting of SEQ ID NO:14.