B7-DC, Dendritic cell co-stimulatory molecules
AssigneeThe Johns Hopkins University
InventorsDrew M. Pardoll, Haruo Tsuchiya, Kevin S. Gorski, Su-Yi Tseng
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Abstract
A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
Claims38
An isolated polypeptide consisting of amino acid residues 26-221 of SEQ ID NO:2 or of SEQ ID NO:4, or a co-stimulatory conservative substitution variant thereof which has the following activities when exposed to T cells:
- (a) binds or PD-1 on the T cells;
- and
- (b) costimulates the T cells to proliferate and/or to produce and secrete cytokines.
Dependencies are inferred from the claim text.