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US 7,030,212 B1Granted
Tumor antigen based on products of the tumor suppressor gene WT1
AssigneeHaruo Sugiyama
InventorsHaruo Sugiyama, Yoshihiro Oka
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Abstract
A tumor antigen that comprises, as an active ingredient, a product of the Wilms', tumor suppressor gene WT1 or a peptide composed of 7–30 contiguous amino acids containing an anchor amino acid for binding to major histocompatibility complex (MHC) class I in said amino acid sequence, and a vaccine comprising said antigen.
Claims9
An isolated polypeptide which consists of at most 12 contiguous amino acid residues of a human WT1 protein, wherein the polypeptide comprises SEQ ID NO:
- 5, binds to MHC proteins, and the polypeptide induces killer T cells when bound to MHC class I antigen.
Dependencies are inferred from the claim text.