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US 7,030,160 B2Granted
Propanolaminotetralines, preparation thereof and compositions containing same
AssigneeSanofi-Aventis
InventorsLaura Barzaghi, Philippe R. Bovy, Roberto Cecchi, Tiziano Croci, Stefano Romagnano
Life of this patent
Estimating the term…
Abstract
The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that are improved by beta-3 agonist action.
Claims20
A compound of formula (I):
- in which:
- R1 and R2 are independently a hydrogen atom, a benzyl group, a benzoyl group, a —CO(C1–C4)Alk group, a —CH2OCH3 group, a —COO(C1–C4)Alk group or a benzyloxycarbonyl group;
- or
- R1 and R2 together form a carbonyl, methylene or di(C1–C4)Alk-methylene group so that R1 and R2 taken together with the oxygen and nitrogen atoms to which they are attached and the carbon atoms of the phenyl moiety to which the O and N atoms are attached form heterocyclyl;
- R3 is a hydrogen atom or a (C1–C4)Alk group;
- R4 is a hydroxyl group, a (C1–C4)alkoxy group or an —NR5R6 group;
- R5 and R6 are independently a hydrogen atom;
- a (C1–C4)Alk group;
- an aryl or heteroaryl group, each of which is optionally substituted with an R7 group;
- an aralkyl or heteroaralkyl group, each of which is optionally substituted with an R7 group;
- or R5 and R6 taken together with the nitrogen atom to which they are attached form a saturated or unsaturated 5 to 7 atom cycle;
- R7 is a hydrogen atom, a halogen atom, a hydroxyl group, a (C1–C4)Alk group, a (C1–C4)alkoxy group, a —COOH group, a —COO(C1–C4)Alk group, a —CN group, an —NH(C1–C4)Alk group or an —N(C1–C4)Alk2 group;
- and
- X is O or CH2;
- or a salt or solvate thereof.
12 more elements
Dependencies are inferred from the claim text.