Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins

A method of enhancing libido in a patient, the method comprising administering to a patient in need thereof a therapeutically effective amount of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or a pharmacologically acceptable acid addition salt thereof, an estrogen and a progestin, provided said patient does not have vaginal atrophy.

A method of treating hypoactive sexual desire disorder in a patient, the method comprising administering to a patient in need thereof a therapeutically effective amonut of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or a pharmacologically acceptable acid addition salt thereof and an estrogen, provided said patient does not have vaginal atrophy.

A method of treating hypoactive sexual desire disorder in a patient, the method comprising administering to a patient in need thereof a therapeutically effective amount of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or a pharmacologically acceptable acid addition salt thereof, an estrogen and a progestin, provided said patient does not have vaginal atrophy.

A method of treating sexual arousal disorder in a patient, the method comprising administering to a patient in need thereof a therapeutically effective amount of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or a pharmacologically acceptable acid addition salt thereof and an estrogen, provided said patient does not have vaginal atrophy.

A method of treating sexual arousal disorder in a patient, the method comprising administering to a patient in need thereof a therapeutically effective amount of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or a pharmacologically acceptable acid addition salt thereof, an estrogen and a progestin, provided said patient does not have vaginal atrophy.

A method of treating dyspareunia in a patient, the method comprising administering to a patient in need thereof a therapeutically effective amonut of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or a pharmacologically acceptable acid addition salt thereof and an estrogen, provided said patient does not have vaginal atrophy.

A method of treating dyspareunia in a patient, the method comprising administering to a patient in need thereof a therapeutically effective amount of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or a pharmacologically acceptable acid addition salt thereof, an estrogen and a progestin, provided said patient does not have vaginal atrophy.

A method of increasing the frequency and intensity of orgasms in a patient, the method comprising administering to a patient in need thereof a therapeutically effective amount of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or a pharmacologically acceptable acid addition salt thereof and an estrogen, provided said patient does not have vaginal atrophy.

A method of increasing the frequency and intensity of orgasms in a patient, the method comprising administering to a patient in need thereof a therapeutically effective amount of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or a pharmacologically acceptable acid addition salt thereof, an estrogen and a progestin, provided said patient does not have vaginal atrophy.

A method of treating vaginismus in a patient, the method comprising administering to a patient in need thereof a therapeutically effective amount of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or a pharmacologically acceptable acid addition salt thereof and an estrogen, provided said patient does not have vaginal atrophy.

A method of treating vaginismus in a patient, the method comprising administering to a patient in need thereof a therapeutically effective amount of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or a pharmacologically acceptable acid addition salt thereof, an estrogen and a progestin, provided said patient does not have vaginal atrophy.