3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents

A compound of Formula I:

• wherein Y is S;
• wherein X is one or more substituents selected from
• a) hydrido, halo, cyano, nitro, hydroxy, acyl, lower alkyl substituted at a substitutable position with a substituent selected from halo, hydroxyl, amino, acylamino, lower alkylamino, lower alkyl(acyl)amino, acyl, aryl optionally substituted with hydroxyl, a heterocyclic group, hydroxyimine and lower alkoxyimino, lower alkenyl optionally substituted at a substitutable position with cyano, amino optionally substituted at a substitutable position with a radical selected from acyl and lower alkylsulfonyl, sulfo, sulfamoyl optionally substituted with a substituent selected from the group consisting of lower alkyl, halo(lower)alkyl, aryl, hydroxyl, lower alkylamino(lower)alkyl, a heterocyclic group and (esterified carboxy)lower alkyl, N-containing heterocyclicsulfonyl, a heterocyclic group optionally substituted at a substitutable position with a substituent selected from the group consisting of hydroxyl, oxo, amino and lower alkylamino,
• b) S(O)nR5, wherein R5 is C1-C7 alkyl optionally substituted at a substitutable position with fluoro, and n is 0, 1 or 2,
• c) C(R6) (OR8) (R7) wherein R6 and R7 independently are selected from CF3, CF2H, CFCl2, CF2Cl, CClFH, CCl2F, CF3CF2 and C1-C2 alkyl, and wherein R8 is selected from hydrido, C1-C4 alkyl, (C1-C3 alkyl)C(O) and CO2R9, wherein R9 is C1-C4 alkyl,
• d) C(O)ZR4, wherein Z is O, N, or S, and R4 is selected from hydrido, C1-C6 alkyl and aryl, and when Z is N then R4 is independently taken twice, and
• e) C(R9) (NHR11) (R10), wherein R9 and R10 are independently selected from CF3, CF2H, CFCl2, CF2Cl, CClFH and CCl2H, and R11 is selected from hydrido and C1-C3 alkyl;
• and
• wherein R2 and R3 are independently selected from aryl or heteroaryl, wherein the aryl or heteroaryl radical is optionally substituted at a substitutable position with a radical selected from halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, nitro, amide, amino, lower alkylamino, sulfamyl and lower alkylsulfonylamino;
• provided that at least one of R2 or R3 is substituted with lower alkylsulfonyl or sulfamyl;
• or a pharmaceutically-acceptable salt thereof.