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US 7,030,148 B2Granted
Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
AssigneeDr. Reddy's Research Foundation
InventorsSelvakumar Natesan, Jagattaran Das, Javed Iqbal, Sitaram Kumar Magadi, Srinivasa Rao Naga Venkata Mamidi, Rajagopalan Ramanujam, Baskaran Sundarababu, Braj Bhushan Lohray
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Abstract
The present invention relates to novel oxazolidinone compounds of the general formula (I) where R1, R2, R3, Y1, Y2, Y3, and Z are as defined in the description; their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutical acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them.
Claims23
A compound of the formula (I)
- wherein
- R1 represents halo, azido, isothiocyanate, thioalcohol, OR4, NHR4 or N(R4)2, where R4 represents substituted or unsubstituted groups selected from acyl, thioacyl, (C1–C6)alkoxycarbonyl, (C3–C6) ycloalkoxythiocarbonyl, (C2–C6) alkenyloxycarbonyl, (C2–C6) alkenylcarbonyl, aryloxycarbonyl, (C1–C6)alkoxythiocarbonyl, (C2–C6)alkenyloxythio-carbonyl, aryloxythiocarbonyl, —C(═O)—C(═O)-alkyl, —C(═O)—C(═O)-aryl, —C(═O)—C(═O)-alkoxy, —C(═O)—C(═O)-aryloxy, —(C═S)—S-alkyl, —(C═S)—NH2, —(C═S)—NH-alkyl, —C(═S)—N-(alkyl)2, —C(═S)—NH-alkenyl, (C═S)—(C═O)-alkoxy, —(C═S)—(C═O)-aryloxy, —C(═S)—O—(C═O)-alkyl, C(═S)—C(═S)-alkyl, —C(═S)—C(S)-aryl, thiomorpholinylthiocarbonyl or pyrrolidinylthiocarbonyl;
- R2 and R3 are same or different and independently represent hydrogen, halogen atom, (C1–C6)alkyl group, halo(C1–C6)alkyl, cyano, nitro, SRa, NRa, ORa where Ra represents substituted or unsubstituted (C1–C6)alkyl group, or halo(C1–C6)alkyl;
- Z represents O,
- Y1 represents ═O or ═S group and Y2 and Y3 independently represent hydrogen, halogen, cyano, nitro, formyl, hydroxy, amino, ═O, ═S group, or substituted or unsubstituted groups selected from (C1–C6)alkyl, hydroxy(C1–C6)alkyl, (C1–C6) alkoxy(C1–C6) alkyl, (C1–C6)alkoxycarbonyl, carboxy(C1–C6)alkyl, (C1–C6)alkylsulfonyl, (C1–C6)alkylcarbonyl-amino(C1–C6) lkyl, arylcarbonylamino(C1–C6)alkyl, (C1–C6) alkylcarbonyloxy(C1–C6)alkyl, amino (C1–C6)alkyl, mono(C1–C6)alkylamino, di(C1–C6)alkylamino, arylamino, (C1–C6)alkoxy, aryl, aryloxy, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl or heterocycloalkyl;
- Y2 and Y3 when present on adjacent carbon atoms together also form a substituted or unsubstituted 5 or 6 membered aromatic or non-aromatic cyclic structure, optionally containing one or two hetero atoms;
- its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates.
4 more elements
Dependencies are inferred from the claim text.