US 7,030,143 B2 · Heterocyclic compounds

Abstract

The present invention provides a preventive or therapeutic agent for hyperlipidemia, comprising as an active ingredient a heterocyclic compound of the formula [1], or a pharmaceutically acceptable salt thereof: wherein: R1 is optionally substituted aryl or aromatic heterocyclic group, Het is a divalent aromatic heterocyclic group, D is alkylene, alkenylene, alkynylene, or the like, and E is carboxy, or the like, and novel compounds among the heterocyclic compounds of the formula [1] above, which has blood triglyceride lowering effect, LDL-C lowering effect, and blood glucose lowering effect and blood insulin lowering effect, or HDL-C increasing effect or atherogenic index lowering effect all together, and hence is useful in the prevention or treatment of hyperlipidemia, arteriosclerosis, diabetes mellitus, hypertension, obesity, and the like.

Claims8

Dependent claims

A heterocyclic compound of the formula [1], or a pharmaceutically acceptable salt thereof:

R1-Het-D-E [1]
wherein:
R1 is aromatic heterocyclic group;
said aromatic heterocyclic group being optionally substituted by the same or different one to three groups selected from alkyl, haloalkyl, trihaloalkyl, alkoxy, halogen and nitro;
Het is an oxazole which is optionally substituted by alkyl or trihaloalkyl;
D is alkylene, alkenylene, or alkynylene;
and
E is a group of the formula [3]:
wherein Y is oxygen or sulfur;
R3 is hydrogen or alkyl;
p is an integer of 0–2;
Z is carboxy, alkoxycarbonyl, hydroxymethyl, carbamoyl, N-hydroxycarbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, cyano, 1H-5-tetrazolyl, 1-alkyl-5-tetrazolyl, or 2-alkyl-5-tetrazolyl.

9 more elements

Dependencies are inferred from the claim text.

Heterocyclic compounds

Life of this patent

Heterocyclic compounds

Life of this patent

Abstract

Claims8