Benzamidine derivatives

A compound of a formula (1), or a pharmacologically acceptable salt or prodrug thereof:

• wherein
• R1 represents a hydrogen atom, a halogen atom, an alkyl group having from 1 to 6 carbon atoms or a hydroxyl group;
• R2 represents a hydrogen atom or a halogen atom;
• R3 represents an alkoxycarbonylalkylsulfonyl group having from 3 to 13 carbon atoms or a carboxyalkylsulfonyl group having from 2 to 7 carbon atoms;
• R4 and R5 are the same or different and each of R4 and R5 represents a hydrogen atom, a halogen atom, an unsubstituted alkyl group having from 1 to 6 carbon atoms, an alkyl group having from 1 to 6 carbon atoms substituted with a halogen atom, an alkoxy group having from 1 to 6 carbon atoms, a carboxyl group, an alkoxycarbonyl group having from 2 to 7 carbon atoms, a carbamoyl group, a monoalkylcarbamoyl group having from 2 to 7 carbon atoms or a dialkylcarbamoyl group having from 3 to 13 carbon atoms;
• R6 represents a hydrogen atom, an unsubstituted alkyl group having from 1 to 6 carbon atoms, a cycloalkyl group having from 3 to 8 carbon atoms, an aralkyl group having from 7 to 16 carbon atoms, an alkyl group having from 1 to 6 carbon atoms substituted with a heterocycle, a carboxyalkyl group having from 2 to 7 carbon atoms, an alkoxycarbonylalkyl group having from 3 to 13 carbon atoms, an aliphatic acyl group having from 2 to 7 carbon atoms, an aromatic acyl group having from 7 to 11 carbon atoms, a carbamoyl group, an alkylsulfonyl group having from 1 to 6 carbon atoms, an aryl group having from 6 to 10 carbon atoms, a heterocycle, a formimidoyl group, a 1-iminoalkyl group having from 3 to 7 carbon atoms, an N-alkylformimidoyl group having from 2 to 7 carbon atoms or an iminoarylmethyl group having from 7 to 11 carbon atoms;
• each of R7 and R8 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms;
• or
• R6 and R7 taken together or R7 and R8 taken together form an alkylene group having from 2 to 5 carbon atoms;
• and
• n represents 0, 1 or 2.