Method of improving bioavailability of orally administered drugs, a method of screening for enhancers of such bioavailability and novel pharmaceutical compositions for oral delivery of drugs
AssigneeCancer Research Ventures Limited
InventorsJohannes Henricus Matthias Schellens, Alfred Hermanus Schinkel
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Abstract
A method for increasing the systemic exposure of cells selected from tumor cells and normal cells to an orally administered pharmaceutically active compound, wherein a bioenhancer comprising an inhibitor of BCRP is orally administered concomitantly with said orally administered pharmaceutically active compound, and in which method the inhibitor is administered simultaneously with the pharmaceutical compound.
Claims13
A method for increasing the bioavailability of at least one orally administered pharmaceutically active compound, wherein said pharmaceutically active compound is selected from the group consisting of camptothecin and a cytostatic camptothecin derivative, said method comprising:
- orally administering an effective bioenhancing amount of GF120918, wherein said GF120918 and said at least one pharmaceutically active compound are concomitantly administered.
Pharmaceutical composition comprising GF120918 and at least one pharmaceutically active compound, wherein said pharmaceutically active compound is selected from the group consisting of camptothecin and a camptothecin derivative.
A pharmaceutical composition, comprising:
- an effective amount of topotecan;
- and
- an effective amount of GF120918 to increase the bioavailability of said topotecan.
A method for increasing the bioavailability of at least one orally administered pharmaceutically active compound, wherein said pharmaceutically active compound is selected from the group consisting of camptothecin and a cytostatic camptothecin derivative, comprising:
- orally administering an effective bioenhancing amount of GF120918, wherein said GF120918 and said at least one pharmaceutically active compound are present at overlapping periods of time.
Dependencies are inferred from the claim text.