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US 7,030,131 B2Granted
Sulfonamide substituted imidazoquinolines
OwnerStephen L. Crooks, Bryon A. Merrillinventors
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Abstract
Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
Claims6
A compound of the formula (I):
- wherein
- bonds represented by the dashed lines are present or absent;
- R1 is —(CH2)2-4—NH—SO2—R4;
- R2 is hydrogen, —C1-4 alkyl, or —C1-4 alkyl-O—C1-4 alkyl;
- R4 is C1-4 alkyl;
- n is 0 and each R present is independently selected from the group consisting of C1-10 alkyl, C1-10 alkoxy, halogen, and trifluoromethyl;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.