Method of treating depression with delta receptor agonist compounds
AssigneeArdent Pharmaceuticals, Inc.
InventorsKwen-Jen Chang, William Pendergast, Peter J. Gengo
Life of this patent
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Abstract
Methods for treatment of depression or other affective mood disorders, such as bipolar manic depression or seasonal affective disorder, are disclosed by administration to a subject suffering or susceptible to same, of therapeutically effective diarylpiperazine compounds as herein described.
Claims8
A method of combating depression in a subject experiencing or susceptible to same, comprising administering to said subject an effective amount of a therapeutic composition, wherein the composition comprises an active agent, wherein the active agent consists of at least one compound selected from the group consisting of:
- where G=O-alkyl, N(alkyl)2, and any other pharmaceutically acceptable esters thereof;
- and pharmaceutically acceptable salts and esters thereof.
A method of combating a mood disorder in a subject experiencing or susceptible to same, comprising administering to said subject an effective amount of a therapeutic composition comprising an active agent, wherein the active agent is at least one compound selected from the group consisting of:
- and pharmaceutically acceptable salts and esters thereof, wherein said mood disorder comprises depression, bipolar manic depression or seasonal affective disorder.
A method of combating a mood disorder in a subject experiencing or susceptible to same, comprising administering to said subject an effective amount of a therapeutic composition comprising an active agent, wherein the active agent consists of at least one compound selected from the group consisting of:
- where G=O-alkyl, N(alkyl)2, and any other pharmaceutically acceptable esters thereof;
- and pharmaceutically acceptable salts and esters thereof, wherein the mood disorder comprises depression, bipolar manic depression or seasonal affective disorder.
A method for combating depression, bipolar manic depression or seasonal affective disorder in a subject experiencing or susceptible to same, comprising:
- affixing a patch to a corporeal locus containing a composition for combating depression, bipolar manic depression or seasonal affective disorder in a subject experiencing or susceptible to same, the composition comprising an active agent, wherein the active agent consists of a member selected from the group consisting of:
- where G=O-alkyl, N(alkyl)2, and any other pharmaceutically acceptable esters thereof;
- and pharmaceutically acceptable salts and esters thereof.
A method of combating depression, bipolar manic depression or seasonal affective disorder in a subject experiencing or susceptible to same, comprising administering to said subject an effective amount of a therapeutic composition comprising an active agent, wherein the active agent consists of a diarylmethylpiperazine compound of the formula:
- wherein:
- Ar1 is 6-member carbocyclic aromatic ring having on a carbon atom thereof a substituent Y, wherein Y is a carboxamide of the formula CONR9R10 where R9 and R10 are both an ethyl group;
- Z is selected from the group consisting of hydrogen, hydroxyl, and alkoxy;
- and
- Ar2 is a 6-member carbocyclic aromatic ring having on a carbon atom thereof a substituent X and wherein X is a halogen or hydrogen
- or a pharmaceutically acceptable ester or salt thereof, wherein the mood disorder comprises depression, bipolar manic depression or seasonal affective disorder.
Dependencies are inferred from the claim text.