Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders

A compound selected from the group consisting of

• 3-Cyano-4-[4-(cyano-phenyl-methyl)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 2-[3-Cyano-6-ethoxycarbonyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-5-ylmethyl]-malonic acid diethyl ester,
• 5-Methyl-4-(4-phenoxy-phenylamino)-6-phenylamino-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid (2-amino-phenyl)-amide,
• 6-(1H-Benzoimidazol-2-yl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• N-[3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl]-2-fluoro-benzamide,
• 5-Methyl-6-(2-methyl-4-oxo-4H-quinazolin-3-yl)-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 6-Benzylamino-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• N-[3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl]-benzenesulfonamide,
• 6-[bis(phenylsulfonyl)amino]-5-methyl-4-[(4-phenoxyphenyl)amino]-7a-hydropyrrolo[1,2-e]pyridazine-3-carbonitrile,
• 6-(Benzothiazol-2-ylamino)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• {4-[4-(6-Chloro-pyridazin-3-yloxy)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester,
• {3-Cyano-5-methyl-4-[4-(1-phenyl-1H-tetrazol-5-yloxy)-phenylamino]-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester,
• {3-Cyano-5-methyl-4-[4-(2-nitro-phenoxy)-phenylamino]-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester,
• {4-[4-(2-Amino-phenoxy)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester,
• {4-[4-(2-Acetylamino-phenoxy)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester,
• 5-Methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• [4-(4-Bromo-phenylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl]-carbamic acid 2-morpholin-4-yl-ethyl ester,
• {3-Cyano-4-[4-(2,2-dimethyl-3-oxo-2,3-dihydro-benzofuran-7-yloxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester,
• 4-(4-{2-[1-(tert-Butoxycarbonylmethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 4-(4-{2-[1-(Carboxymethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 3-Cyano-4-(4-{2-[1-(ethylcarbamoylmethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 4-(1-Benzyl-piperidin-4-ylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 3-Cyano-5-methyl-4-(4-phenoxy-benzenesulfonyl)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethylester,
• 3-Cyano-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 3-Cyano-5-methyl-4-[4-phenoxy-3-(tetrahydro-pyran-2-yloxymethyl)-phenylamino]-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 3-Cyano-4-(3-hydroxymethyl-4-phenoxy-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 6-(1-Hydroxy-1-methyl-ethyl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• Trifluoro-methanesulfonic acid 3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl ester,
• 6-(1-Hydroxy-1methyl-ethyl)-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 6-Hydroxy-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 5,6-Dimethoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 6-(4-Methoxy-phenyl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 5-Methyl-4-(4-phenoxy-phenylamino)-6-phenyl-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 3-Cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 7-Bromo-3-cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 7-Chloro-3-cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 3-Cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-7-carboxylic acid ethyl ester,
• 7-Hydroxymethyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 3-Cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-7-carboxylic acid,
• 3-Cyano-5,7-dimethyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 5-Methyl-6-(4-methyl-piperazin-1-ylmethyl)-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile
• [3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-ylmethoxy]-acetic acid ethylester,
• 3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carbonyl-N-hydroxylacetamidine,
• 6-(Hydroxyimino-methyl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• N-Benzyl-N-[3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-ylmethyl]-acetamide,
• N-[3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl]-methanesulfonamide,
• 5-Methyl-6-(3-methyl-[1,2,4]oxadiazol-5-yl)-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methoxy-methyl-amide,
• 5-Methyl-4-(4-phenoxy-phenylamino)-6-propynoyl-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carbonyl-N-hydroxymorpholinyl-acetamidine,
• 5-Methyl-6-(3-morpholin-4-yl-[1,2,4]oxadiazol-5-yl)-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 6-(3-Methanesulfonylmethyl-[1,2,4]oxadiazol-5-yl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 3-(Imino-hydrazino-methyl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 5-Methyl-4-(4-phenoxy-phenylamino)-6-(4-phenyl-thiazol-2-yl)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 6-(4,5-Dihydro-1H-imidazol-2-ylamino)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 6-(2-Amino-4-hydroxy-4,5-dihydro-thiazol-4-ylamino)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ether ester,
• 3-Cyano-4-[2-fluoro-4-(thiazol-2-yloxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 1-{4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-(2-morpholin-4-yl-ethyl)-urea,
• 3-Cyano-5-methyl-4-(5-phenoxy-pyridin-2-ylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 3-Acetylamino-N-{3-cyano-4-[5-(2-methoxy-phenoxy)-pyridin-2-ylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-benzamide,
• 3-Acetylamino-N-{3-cyano-4-[5-(2-methoxy-phenoxy)-pyridin-2-ylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-benzamide,
• {3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-methyl-carbamic acid 2-morpholin-4-yl-ethyl ester,
• [3-Cyano-4-(4-{2-[1-(2-hydroxy-ethylcarbamoyl)-1-methoxy-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl]-carbamic acid 2-morpholin-4-yl-ethyl ester,
• N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-methanesulfonylamino-benzamide,
• 5-Methyl-6-morpholin-4-ylmethyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 1-{3-Cyano-4-[2-fluoro-4-(thiazol-2-yloxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-(2-morpholin-4-yl-ethyl)-urea,
• 3-Cyano-4-(4-{2-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• {4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester,
• 3-Cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid,
• {3-Cyano-4-[2-fluoro-4-(thiazol-2-yloxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-carbamic acid 2-morpholin-4-yl-ethyl ester,
• 3-Cyano-5-methyl-4-(2-methyl-4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 3-Cyano-4-(2-fluoro-4-phenoxy-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 3-Cyano-4-(4-{2-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 3-Cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-7-carboxylic acid,
• 4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid (2-morpholin-4-yl-ethyl)-amide,
• 4-(5-Bromo-pyridin-2-ylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• [3-Cyano-4-(4-{2-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl]-carbamic acid 2-morpholin-4-yl-ethyl ester,
• 3-Cyano-4-(4-hydroxy-cyclohexylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 4-(7-Aza-bicyclo[2.2.1]hept-7-yl)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 4-(4-tert-Butoxycarbonyl-piperazin-1-yl)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 3-Cyano-5-methyl-4-piperazin-1-yl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 4-(4-Benzoyl-piperazin-1-yl)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 4-(1-tert-Butoxycarbonyl-piperidin-4-ylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 3-Cyano-4-(4-methanesulfonyl-piperazin-1-yl)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 3-Cyano-5-methyl-4-(piperidin-4-ylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 4-(1-Acetyl-piperidin-4-ylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 6-Formyl-7-iodo-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• [3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl]-carbamic acid 4-methanesulfonyl-butyl ester,
• 3-Cyano-4-(4-{3-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• [3-Cyano-4-(4-{3-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl]-carbamic acid 2-morpholin-4-yl-ethyl ester,
• 4-{4-[2-(1-tert-Butoxycarbonyl-1-methyl-ethoxy)-phenoxy]-phenylamino}-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 4-{4-[2-(1-Carboxy-1-methyl-ethoxy)-phenoxy]-phenylamino}-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 3-Acetylamino-N-[3-cyano-4-(4-{3-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl]-benzamide,
• 3-Cyano-4-(4-{2-[1-(ethylcarbamoylmethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 3-Cyano-4-(4-{2-[1-(ethoxycarbonylmethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 3-Cyano-5-methyl-4-[4-phenoxy-3-(2,2,2-trifluoro-acetoxymethyl)-phenylamino]-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 5-Amino-3-cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 4-(4-{2-[1-(tert-Butoxycarbonylmethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 6-Hydroxy-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 7-Chloro-3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 7-Bromo-3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 3-Cyano-4-{4-[2-(2,3-dihydroxy-propoxy)-phenoxy]-phenylamino}-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 3-Cyano-5-methyl-4-(4-phenoxy-benzoylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 3-Cyano-5-methyl-4-(4-phenoxy-benzenesulfonylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 6-{3-[2-(1,1-Dioxo-1l6-thiomorpholin-4-yl)-ethyl]-2-oxo-imidazoline-1-carbonyl]-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 3-Cyano-5-methyl-4-[4-(pyridin-2-yloxy)-phenylamino]-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 3-Cyano-5-methyl-4-[4-(pyridin-4-yloxy)-phenylamino]-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 3-Cyano-5-methyl-4-[4-(pyridin-3-yloxy)-phenylamino]-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 4-Acetylamino-N-{3-cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-benzamide,
• 3-Acetylamino-N-{3-cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-benzamide,
• N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-dimethylamino-benzamide,
• N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-dimethylamino-benzamide,
• 1H-Benzoimidazole-5-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide,
• 1H-Benzoimidazole-5-carboxylic acid {3-cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide,
• 3-Cyano-4-(4-{2-[1-(ethylcarbamoylmethyl-carbamoyl)-1-methyl-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 4-Benzenesulfonyl-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 6-Isopropenyl-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 3-[3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yloxy]-propane-1-sulfonic acid,
• (3-Morpholin-4-yl-propyl)-carbamic acid 3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl ester,
• 5-Methyl-4-(4-phenoxy-phenylamino)-6-pyridin-2-yl-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 3-Cyano-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid,
• (2-Morpholin-4-yl-ethyl)-carbamic acid 3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl ester,
• (2-Morpholin-4-yl-ethyl)-carbamic acid 3-cyano-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl ester,
• 3-[3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yloxycarbonylamino]-propionic acid,
• 6-(3H-Imidazol-4-yl)-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo]1,2-b]pyridazine-3-carbonitrile,
• Furan-2-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide,
• Thiophene-2-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide,
• 3-Cyano-4-{4-[2-(3-hydroxy-2,2-bis-hydroxymethyl-propoxy)-phenoxy]-phenylamino}-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-4-morpholin-4-yl-benzamide,
• N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-2-methanesulfonyl-benzamide,
• 2-Oxo-imidazolidine-1-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide,
• Benzo[1,2,5]thiadiazole-5-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide,
• 5-Methanesulfonyl-thiophene-2-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide
• 3-Chloro-4-methanesulfonyl-thiophene-2-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide,
• [1,2,3Thiadiazole-4-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide,
• 3,5-Bis-acetylamino-N-{3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-d]pyridazin-6-yl}-benzamide,
• N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-4-guanidino-benzamide;
• trifluoro-acetic acid salt,
• N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-nitro-benzamide,
• N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-4-nitro-benzamide,
• N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-guanidino-benzamide;
• trifluoro-acetic acid salt,
• 3-Amino-N-{3-cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-benzamide,
• N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-ureido-benzamide,
• N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-4-guanidino-benzamide,
• N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-ureido-benzamide, trifluoro-acetic acid salt,
• N-{3-Cyano-4-[4-(3-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-4-guanidino-benzamide, trifluoro-acetic acid salt,
• 3,4-Bis-acetylamino-N-{3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-benzamide,
• 2-Oxo-2,3-dihydro-1H-indole-6-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide,
• 2-Oxo-2,3-dihydro-1H-benzoimidazole-5-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide,
• 2,3-Dioxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide,
• Thiophene-2-carboxylic acid {3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-amide,
• 1H-Imidazole-2-carboxylic acid [3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazin-6-yl]-amide,
• 5-Methyl-4-(4-phenoxy-phenylamino)-7-phenyl-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 4-[4-(2-Methoxy-phenoxy)-phenylamino]-5-methyl-6-(pyrimidin-2-ylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-guanidine;
• trifluoro-acetic acid salt,
• 4-[4-(2-Methoxy-phenoxy)-phenylamino]-5-methyl-6-(pyridin-2-ylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 6-(Di-pyrazin-2-yl-amino)-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• 4-[4-(2-Methoxy-phenoxy)-phenylamino]-5-methyl-6-(pyrazin-2-ylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile,
• Acetic acid (3-{3-cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-ylcarbamoyl}-phenylcarbamoyl)-methyl ester,
• N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-nitro-benzamide,
• 4-(1-Benzoyl-piperidin-4-ylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 4-(4-Acetyl-piperazin-1-yl)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• N-{3-Cyano-4-[4-(2-methoxy-phenoxy)-phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl}-3-(3-ethyl-ureido)-benzamide,
• 3-Cyano-5,7-dimethyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester,
• 7-Chloro-3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 7-Bromo-3-cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 3-Cyano-4-{4-[2-(2,3-dihydroxy-propoxy)-phenoxy]-phenylamino}-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 3-Cyano-4-{4-[2-(3-hydroxy-2,2-bis-hydroxymethyl-propoxy)-phenoxy]-phenylamino}-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• 3-Cyano-4-{4-[2-(2-hydroxy-ethoxy)phenoxy]-phenylamino}-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester, and
• 3-Cyano-4-(4-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-phenoxy}-phenylamino)-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester,
• or a pharmaceutically acceptable salt thereof.