Highly bioavailable coenzyme Q-10 cyclodextrin complex
AssigneeBioActives, LLC
InventorsDoddabele L. Madhavi, Daniel I. Kagan
Life of this patent
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Abstract
The present invention is based on the unexpected discovery that CoQ-10 can be made commercially in a highly bioavailable form suitable for topical, sublingual formulations, or for oral ingestion. One such bioavailable form is a water dispersible freeze-dried CoQ-10/γ-cyclodextrin complex. Complexation in general with γ- or α-cyclodextrin improved the cellular uptake of CoQ-10 as compared to water dispersible liposomal or micellar forms of CoQ-10. Thus, the present invention includes a highly bioavailable CoQ-10/cyclodextrin complex for use in the nutritional supplement, oral care, and pharmaceutical industry.
Claims17
A water-dispersible, freeze-dried bioavailable complex of coenzyme Q-10 and one or more of α-, β- or γ-cyclodextrin, wherein the molar ratio of cyclodextrin to coenzyme Q-10 rages from about 0.5:1 to 10:1.
A method for making a water-dispersible complex, which comprises the steps of:
- (a) preparing an aqueous slurry of a complex of coenzyme Q-10 and one or more of α-, β- or γ-cyclodextrin by adding coenzyme Q-10 to an aqueous dispersion of one or more of α-, β- or γ-cyclodextrin, wherein the molar ratio of cyclodextrin to coenzyme Q-10 rages from about 0.5:1 to 10:1;
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- (b) drying by one or more of spray drying, vacuum-drying, or freeze drying, said aqueous slurry to produce said complex.
In a method for administering to an animal in need thereof a bioavailable
- (a) preparing a water-dispersible complex of coenzyme Q-10 and one or more of α-, β- or γ-cyclodextrin by adding coenzyme Q-10 to an aqueous dispersion of one or more of α-, β- or γ-cyclodextrin, wherein the molar ratio of cyclodextrin to coenzyme Q-10 rages from about 0.5:1 to 10:1;
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- (b) administering said complex to said animal.
A method for making a water-dispersible complex, which comprises the steps of:
- (a) preparing an aqueous slurry of a complex of coenzyme Q-10 and one or more of α-, β- or γ-cyclodextrin by adding coenzyme Q-10 to an aqueous dispersion of one or more of α-, β- or γ-cyclodextrin at room temperature using homogenization followed by storage under refrigeration;
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- (b) drying by one or more of spray drying, vacuum-drying, or freeze drying, said aqueous slurry to produce said complex.
In a method for administering to an animal in need thereof a bioavailable coenzyme Q-10 complex, said coenzyme Q-10 being useful for treating disease conditions comprising cardiovascular disease, periodontal disease, high blood pressure, Parkinson's disease, skin care, and oral health care, which comprises the steps of:
- (a) preparing a water-dispersible complex of coenzyme Q-10 and one or more of α-, β- or γ-cyclodextrin by adding coenzyme Q-10 to an aqueous dispersion of one or more of α-, β- or γ-cyclodextrin at room temperature using homogenization followed by storage under refrigeration;
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- (b) administering said complex to said animal.
Dependencies are inferred from the claim text.