Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and QS-21
AssigneesCorixa Corporation, Antigenics Inc.
InventorsSally Mossman, Lawrence Evans
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Abstract
The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising RC-529 (an aminoalkyl glucosaminide phosphate compound) and QS-21 (a saponin). Such compositions synergistically enhance the immune response in a mammal to a co-administered antigen. Also provided are methods of using the compositions in the treatment of various human diseases, including cancer, microbial infections and autoimmune disorders.
Claims27
An aqueous immunostimulant composition comprising QS-21 and 2-[(R)-3-Tetradecanoyloxytetradecanoylamino]ethyl-2-Deoxy-4-O-phosphono-3-O-[(R)-3-tetradecanoyloxytetradecanoyl]-2-[(R)-3-tetradecanoyloxytetradecanoylamino]-β-D-glucopyranoside or its triethylammonium salt.
An immunostimulant composition comprising QS-21 and 2-[(R)-3-Tetradecanoyloxytetradecanoylamino]ethyl-2-Deoxy-4-O-phosphono-3-O-[(R)-3-tetradecanoyloxytetradecanoyl]-2-[(R)-3-tetradecanoyloxytetradecanoylamino]-β-D-glucopyranoside or its triethylammonium salt in an aqueous formulation comprising one or more phospholipid surfactants selected from the group consisting of dimyristoyl phosphatidyl glycerol (DPMG), dipalmitoyl phosphatidyl glycerol (DPPG), distearoyl phosphatidyl glycerol (DSPG), dimyristoyl phosphatidylcholine (DPMC), dipalmitoyl phosphatidylcholine (DPPC), distearoyl phosphatidylcholine (DSPC);
- dimyristoyl phosphatidic acid (DPMA), dipalmitoyl phosphatidic acid (DPPA), distearoyl phosphatidic acid (DSPA);
- dimyristoyl phosphatidyl ethanolamine (DPME), dipalmitoyl phosphatidyl ethanolamine (DPPE) and distearoyl phosphatidyl ethanolamine (DSPE).
Dependencies are inferred from the claim text.