Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione
AssigneePharmacia Italia S.p.A.
InventorsMaria Cristina Geroni, Paolo Cozzi, Italo Beria
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Abstract
Compounds which are α-halogenoacryloyl distamycin derivatives of formula (I) wherein R1 is a bromine or chlorine atom; R2 is a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceutically acceptable salt thereof; are cytotoxic agents particularly effective in the treatment of tumors over expressing GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies.
Claims16
A method for the treatment of tumors in humans overexpressing GSH/GSTs comprising administering to said human an α-halogenoacryloyl distamycin derivative of formula (I)
- wherein:
- R1 is a bromine or chlorine atom;
- and
- R2 is a distamycin or distamycin-like framework;
- or an acceptable salt thereof.
Dependencies are inferred from the claim text.