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US 7,030,084 B2Granted
Drug-oligomer conjugates with polyethylene glycol components
AssigneeNobex Corporation
InventorsNnochiri N. Ekwuribe, Muthukumar Ramaswamy, Jayanthi Rajagopalan
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Abstract
The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, and oleic acid can be orally administered.
Claims12
A drug-oligomer conjugate having the formula:
- D—Hp
- wherein D is a therapeutic drug moiety selected from the group consisting of insulin, insulin lispro, and a functional equivalent of insulin;
- H is a PEG polymer having from 1 to 7 PEG units;
- and
- p is a number from 1 to the maximum number of covalent bonding sites at which —H can form a bond with D.
2 more elements
A drug-PEG conjugate having the formula:
- D—Hp
- wherein D is selected from the group consisting of insulin, insulin lispro, and a functional equivalent of insulin;
- H is a PEG polymer having from 1 to 7 PEG units;
- and
- p is a number from 1 to the maximum number of covalent bonding sites at which
- —H can form a bond with D,
- wherein the drug-PEG conjugate has enhanced activity in comparison with a corresponding unconjugated insulin molecule, unconjugated insulin lispro molecule or unconjugated functional equivalent thereof.
4 more elements
Dependencies are inferred from the claim text.