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AssigneeNobex Corporation
InventorsRichard Soltero, Nnochiri N. Ekwuribe, Foyeke Opawale, Bruce Rehlaender, Anthony Hickey, Li Li Bovet
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Pharmaceutical compositions that include a drug and/or drug-oligomer conjugate, a fatty acid component and a bile salt component, or a bile salt component without a fatty acid component are described. The drug can be covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component, when together, can be present in a weight-to-weight ratio of between 1:15 and 15:1 or any value between. Methods of treating diseases in a subject in need of such treatment using the pharmaceutical compositions of this invention are also provided, as well as methods of providing such pharmaceutical compositions.
A pharmaceutical composition comprising (a) a drug-oligomer conjugate comprising a drug covalently coupled to an oligomeric moiety, wherein the oligomeric moiety is hydrophilic, (b) a bile salt, and (c) a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising (a) a drug-oligomer conjugate comprising a drug covalently coupled to an oligomeric moiety, wherein the oligomeric moiety is alkane, (b) a bile salt, and (c) a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising, in a pharmaceutically acceptable carrier:
A method of treating a bone disorder in a subject in need of such treatment, said method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising (a) a drug-oligomer conjugate comprising a drug covalently coupled to an oligomeric moiety, (b) a bile salt, and (c) a pharmaceutically acceptable carrier, by an administration route selected from the group consisting of buccal, transdermal, peroral and nasal administration.
A method of treating bone disorder in a subject in need of such treatment, said method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising (a) a drug-oligomer conjugate comprising a drug covalently coupled to an oligomeric moiety, wherein the oligomeric moiety is hydrophilic, (b) a bile salt, and (c) a pharmaceutically acceptable carrier.
A method of treating bone disorder in a subject in need of such treatment, said method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising (a) a drug-oligomer conjugate comprising a drug covalently coupled to an oligomeric moiety, wherein the oligomeric moiety is alkane, (b) a bile salt, and (c) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.