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US 7,029,918 B2Granted
Water-soluble derivatives of lipophilic drugs
AssigneeRoche Diagnostics Operations, Inc.
InventorsMin Li, Robert S. Wu, Jane S. C. Tsai
Life of this patent
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Abstract
A water-soluble reference standard is useful for immunoassays of a lipophilic drugs. The reference standard is a compound of formula (I): G-(L)n—Y; (I) where G is a lipophilic drug; L is a linker which is an alkyl group or heteroalkyl group containing from 1 to 20 carbon atoms; n is 0 or 1; and Y is a water-solubilizing group such as —SO3−, —NR—SO3−, —P(═O)(OH)(O−), or —O—P(═O)(OH)(O−); where R is H or an alkyl group of 1 to 10 carbon atoms.
Claims3
A water-soluble reference standard of formula (II)
- wherein X1, X2, X3 and X4 are independently selected from the group consisting of hydrogen, F, Cl, Br, nitro, amino, and alkylamido;
- -L- is —CH2CH2—;
- -E is —H, alkyl, —OH, —COOH, or COOR′, where R′ is an alkyl group containing from 1 to 10 carbon atoms;
- A is an aryl group;
- n is 1;
- and Y is —NHSO3.
3 more elements
Dependencies are inferred from the claim text.