Carbonyl stress-ameliorating agents
AssigneesToshio Miyata, Kiyoshi Kurokawa, Tokai University Education System
InventorToshio Miyata
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Abstract
Carbonyl stress-ameliorating agents have been provided, which contain an enzyme having a glyoxalase I activity and a carbonyl compound-reducing agent as the active ingredients. The carbonyl stress-ameliorating agents of the present invention rapidly eliminate carbonyl compounds, and thus ameliorate carbonyl induced stress conditions.
Claims7
A method for detoxifying 3-deoxyglucosone in blood or a peritoneal dialysate, comprising the step of contacting said blood or peritoneal dialysate with a purified enzyme having an activity of at least 10 units/ml of glyoxalase I activity in the presence of a carbonyl compound reducing agent in a concentration of at least 1 mM, wherein said 3-deoxyglucosone in said blood or peritoneal dialysate is enzymatically detoxified.
Dependencies are inferred from the claim text.