Iodine uptake restoration in thyroid cancer
AssigneeUniversity of Kentucky Research Foundation
InventorsKenneth B. Ain, Gopalakrishnan Venkataraman
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Abstract
A method of expressing a tumor specific therapeutic response element in a cancerous cell is disclosed in which the response element was previously blocked from expression. The method comprises the step of administering an unblocking agent to the cancerous cell harboring a gene encoding the response element, thereby resulting in the expression of the response element.
Claims10
A method for introducing iodide into a human thyroid carcinoma cell containing a silenced endogenous gene encoding human sodium/iodide symporter comprising administering to the cell a compound selected from the group consisting of 5-azacytidine, sodium butyrate, dimethylsulfoxide, adenosyl-1,8-diamino-3-thio-octane, and phenylacetate;
- and
- administering to the cell radiolabeled iodide.
A method for restoring iodide transport to a human thyroid carcinoma cell comprising administering 5-azacytidine to the cell in an amount effective to transcriptionally activate the expression of a gene encoding the human sodium/iodide symporter.
A method of restoring iodide transport to a human thyroid carcinoma cell comprising administering difluoromethylornithine or adenosyl-1,8-diamino-3-thio-octane to the cell in an amount effective to transcriptionally activate the expression of a gene encoding the human sodium/iodide symporter, and
- administering to the cell radiolabeled iodide.
Dependencies are inferred from the claim text.