Melanin concentrating hormone receptor chimeric and fusion proteins
AssigneeMerck & Co., Inc.
InventorDonald J. Marsh
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Abstract
The present invention features melanin concentrating hormone receptor (MCH-R) chimeric and fusion proteins. MCH-R chimeric proteins comprise an MCH-R polypeptide region made up of at least two or more polypeptide regions characteristic of MCH-R found in different species. MCH-R fusion proteins comprise an MCH-R polypeptide region and a fluorescent protein region.
Claims19
A protein comprising a melanin concentrating hormone receptor polypeptide region selected from the group consisting of:
- SEQ ID NO:
- 4, SEQ ID NO:
- 5 or SEQ ID NO:
- 11.
A nucleic acid comprising a nucleotide sequence encoding a protein comprising a melanin concentrating hormone receptor polypeptide region selected from the group consisting of:
- SEQ ID NO:
- 4 and SEQ ID NO:
- 5.
A method for assaying for melanin concentrating hormone receptor active compounds comprising the steps of:
- a) contacting a recombinant cell with a test preparation comprising one or more test compounds, wherein said recombinant cell comprises a nucleotide sequence encoding a protein comprising a melanin concentrating hormone receptor polypeptide region selected from the group consisting of:
- SEQ ID NO:
- 4 and SEQ ID NO:
- 5;
- and
- b) measuring the effect of said test preparation on one or more melanin concentrating hormone receptor activities.
Dependencies are inferred from the claim text.