Secreted and transmembrane polypeptides and nucleic acids encoding the same

An isolated nucleic acid comprising a nucleic acid sequence encoding SEQ ID NO:483, lacking its associated signal peptide.

An isolated nucleic acid comprising a nucleic acid sequence encoding an extracellular domain of SEQ ID NO:483.

An isolated nucleic acid comprising SEQ ID NO:482.

An isolated nucleic acid comprising the full-length coding sequence of SEQ NO:482.

An isolated nucleic acid comprising the full-length coding sequence of the cDNA deposited under accession number 209859.

An isolated nucleic acid that hybridizes under high stringecy conditions of 50% formamide, 5×SSC (0.75 M NaCl, 0.075 M sodium citrate), 50 mM sodiu phosphate (pH 6.8), 0.1% sodium pyrophosphate, 5×Denhardt's solution, sonicated salmon sperm DNA (50 μg/ml), 0.1% SDS, and 10% dextran sulfate at 42° C., with washes at 42° C. in 0.2×SSC (sodium chloride/sodium citrate) and 50% formamide at 55° C., followed by a high-stringenc wash consisting of 0.1×SSC containing EDTA at 55° C. to the complement of the nucleic acid in ecule shown as SEQ ID NO:482, wherein said isolated nucleic acid encodes a polypeptide that includes chondrocyte differentiation.

An isolated nucleic acid that hybridizes under high stringency conditions of 50% formamide, 5×SSC (0.75 M NaCl, 0.075 M sodium citrate), 50 mM sodiu phosphate (pH 6.8), 0.1% sodium pyrophosphate, 5×Denhardt's solution, sonicated salmon rm DNA (50 μ/ml), 0.1% SDS, and 10% dextran sulfate at 42° C., with washes at 42° C. in 0.2×SSC (sodium chloride/sodium citrate) and 50% formamide at 55° C., followed by a high-stringency wash consisting of 0.1×SSC containing EDTA at 55° C. to the complement of the nucleic acid m ecule shown as SEQ ID NO:482, wherein said isolated nucleic acid encodes a polypeptide at inhibits the proliferation of T lymphocytes.