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US 7,029,867 B2Granted
Method of assaying antilaminin-1 antibody and application thereof
AssigneeEiji Matsuura
InventorsEiji Matsuura, Junko Inagaki, Koji Aoki
Life of this patent
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Abstract
By allowing serum or plasma samples collected from humans to react with laminin-1 or a fragment thereof, and then determining whether or not anti-laminin-1 antibody, an auto-antibody against laminin-1, in the sample bound to laminin-1 to detect anti-laminin-1 antibody in the sample, gynecology-related diseases such as habitual abortion, sterility, infertility, and endometriosis can be diagnosed.
Claims4
A method for diagnosing endometriosis in an infertile female suspected of having endometriosis, which comprises the steps of:
- (a) reacting a test sample from the infertile female suspected of having endometriosis with laminin-1 or a fragment thereof to thereby bind anti-laminin-1 antibody in the test sample to the laminin-1 or fragment;
- (b) determining an amount of the anti-laminin-1 antibody in the test sample which is bound to the laminin-1 or fragment;
- (c) comparing the amount of bound anti-laminin-1 antibody in the test sample with the amount of bound anti-laminin-1 antibody in a control sample from a healthy female, wherein a higher amount of bound anti-laminin-1 antibody in the test sample is indicative of a diagnosis of endometriosis.
Dependencies are inferred from the claim text.